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Hello. This is another great question. From what I understand, Brodalumab is still in phase 3, the final stage of clinical trials. However, based on limited information from the clinical trial and it’s mechanism of action it seems to block several of the possible contributing factors of plaque psoriasis. There are two doses of the medication, a low dose (140 mg) and a high dose (210mg) to be given as an injection under the skin. I found from the clinical data that patients have experienced up to 100% full clearance in the symptoms of plaque psoriasis at about 3 months of treatment, namely the painful redness, scaliness, and thickness of skin. The only information I’ve found about adverse events states patients have experienced upper respiratory tract infections and headaches probably due to mild suppression of the immune system by the medication. With limited information available, a lot remains to be discovered about the medication from the clinical trial. Also we will need head-to-head clinical trials of Brodalumab vs. current therapies to understand where it fits along the continuum of available treatments. However, it seems like a promising therapy. I hope this helps for now.
Great question. There are several treatment options for Crohn’s disease. The medications available work to reduce the inflammation throughout the GI tract. Also medications are use to lower hyperactivity of the immune system. There are several classes of medications available, i.e., Imuran (azathioprine), methotrexate, prednisone, humira, remicade infusions, etc. The medications do a great job and work rapidly to get symptoms under control and slow the progression of Crohn’s disease, however the side effect profile is extensive. Proceed with caution and manage your medication carefully. I also recommend researching the Specific Carbohydrate Diet (SCD), the diet and lifestyle change has helped many patients manage their symptoms of Crohn’s Disease.
Great questions. First, determining the cause by your physician is critical in this situation. If having high thyroid levels (hyperthyroidism) is the cause for the thyroid nodule, then yes medications and a medication strategy can be used to reduce the high thyroid levels which should shrink/dissolve the nodule. Furthermore; if you elect surgery, lifelong medication is not necessarily required, the decision for lifelong medication will be based on the severity of your symptoms and thyroid levels after the surgery.